Respuesta :
The interior of the neuron is negative than the outside due to the presence of protein and chloride ions.
In contrast to the positive charge in an extracellular matrix, neurons actually have a strong negative charge inside them. This is due to the abundant accumulation of anions (negatively charged ions).
These anions are large molecules which cannot leave through any channel. So, they simply stay put and give the cell a negative charge inside.
The commonly present anion is chloride ion which keeps the neuron resting membrane potential in -70mV. If the neuron needs to conduct electrical impulse, neuron will then reach +40mV action potential by opening many cation channels (for example, Na/k channel).
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The interior of the neuron is negative than the outside due to the presence of protein and chloride ions.
Why is a neuron charged even at resting state?
- At rest, a neuron is negatively charged.
- A typical neuron has -70 mV charge on it, i.e., it is 70 mV more negative on inside than outside.
- In a resting neuron, there is more K+ on the inside the cell than outside and more Na+ on the outside than inside.
- For each potassium ion present, there is an organic anion to balance it.
- Therefore organic anions like those of amino acids and proteins are in higher concentrations on the inside of cell than outside.
- Also the membranes are leaky for K+ as it can pass with the help of K+ channels causing positive charge to move outside the cell. However, the organic anions cannot move out resulting in more negative charge inside the cell.
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