When the total body surface area burned exceeds 20 percent, the systemic inflammatory response is initiated.
What is systemic inflammatory response?
- In order to pinpoint and ultimately eradicate the endogenous or external source of the insult, the body overreacts in its defense against unpleasant stressors including infections, trauma, surgery, acute inflammation, ischemia or reperfusion, or cancer, to mention a few.
- The dysregulated release of acute and chronic phase reactants is at the core of the clinical scenario, which also involves dysregulation of the proinflammatory and anti-inflammatory system homeostasis.
Basically, The body's overactive defense reaction to a harmful stressor is known as the systemic inflammatory response syndrome (SIRS), which aims to identify and then eradicate the endogenous or external source of the insult.
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