The highest level of evidence consists of the systematic review (SR) and meta-analysis using two or more randomized controlled trials (RCTs) of human subjects.
Option D is correct.
Levels of evidence pyramid---
The levels of evidence pyramid provides a way to visualize both the quality of evidence and the amount of evidence available. For example, systematic reviews are at the top of the pyramid, meaning they are both the highest level of evidence and the least common. As you go down the pyramid, the amount of evidence will increase as the quality of the evidence decreases.
systematic review ----ask a specific clinical question, perform a comprehensive literature review, eliminate the poorly done studies, and attempt to make practice recommendations based on the well-done studies. Systematic reviews include only experimental, or quantitative, studies, and often include only randomized controlled trials.
Learn more about Pyramid of evidences:
brainly.com/question/14188794
#SPJ4