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The information simply means that America's cause is to create a better society with opportunities that the people deserve and to resist tyranny as all mankind have tried throughout history.
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It should be noted that Paine divided Common Sense into four sections with mundane titles, mimicking the erudite political pamphlets of the day.
The cause of America is, in a great measure, the cause of all mankind. Several circumstances have, and will arise, which are not local, but are universal, and through which the principles of all lovers of mankind are affected, and in the event of which, their affections are interested.
When Thomas Paine says, “The cause of America is in a great measure the cause of all mankind”, he means the problems to inhabitants of America's government are the same causes of issues within the people in society.
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