DNA ligase joints together the Okazaki fragment of DNA in the lagging strand.
DNA ligase is the enzyme .it catalyses the formation of a phosphodiester bond between the 3'OH group at the end of one DNA fragment and the 5'phosphate group at the end of another.
During DNA replication in the lagging strand, okazaki fragments are formed because due to different primer are available for DNA polymerase enzyme. so the new DNA strand takes place in discontinuous manner. DNA ligase enzyme act as molecular suture . it s form phosphodiester bond between 3'OH group of one DNA to 5'phosphate group of another DNA molecule. so the newly synthesised DNA takes place in continuous manner.
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