If an organism with a particular genotype fails to produce the corresponding phenotype, the organism is said to be non-penetrant for the trait.
Non- penetrance is an instance in which an individual has a trait-associated or disease-causing genetic variant, but the individual does not have the phenotype.
The individual in whom such a nonpenetrant mutant gene exists will be phenotypically normal but still capable of passing the deleterious gene on to offspring, who may exhibit the full-blown disease.
An example of non-penetrance is a woman with a BRCA1 pathogenic variant who lives to be elderly and never develops breast or ovarian cancer.
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