The words "breach in nature" represent the idea that Duncan's murder is a disruption of the order.
In "Macbeth" we find that Duncan was a good king, with few enemies and much admired, in addition to having good health. This shows that Duncan's death was not something that should have happened and if it did, it should be from natural causes and not precociously through murder.
This murder caused Duncan to lose his life at the wrong time, making the environment disharmonious and corrupted as a "breach in nature."
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