The meselson-stahl experiment demonstrated that DNA replication produces two DNA molecules each composed of nitrogen isotopes.
Matthew Stanley Meselson and Franklin William Stahl in the US demonstrated semi-conservative DNA replication in the 1950s, showing that each daughter DNA molecule contains one new daughter subunit and one subunit conserved from the mother DNA molecule. This work was later named after them. Meselson and Stahl came to the conclusion that DNA molecules can reflect semi-conservatively based on their observations and experimental findings. The study of the semi-conservative character of DNA replication or the copying of cells did not end there.
The DNA replication process was examined in a 1958 experiment by Matthew Meselson and Franklin Stahl using the fast-dividing E. coli bacterium. By centrifuging nitrogen isotopes in calcium chloride, 15N (heavy) and 14N (normal) can be distinguished from one another based solely on their densities (CsCl).
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