The role of the calcium ions during an action potential the calcium causes the release of acetylcholine.
Cellular physiology and biochemistry of organisms are influenced by calcium ions (Ca2+). They are essential for neurotransmitter release from neurons, all forms of muscle cell contraction, fertilization, and signal transduction pathways where they function as a second messenger. Many enzymes, including several of the coagulation factors, require calcium ions as a cofactor. In order to maintain the potential difference across excitable cell membranes and to ensure normal bone development, extracellular calcium is also crucial. RDAs for calcium were established by the American Institute of Medicine (IOM) in 1997, and they were revised in 2011.
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