Albert Kelner discovered that sunlight can repair UV damage. This seems counterintuitive but was later explained by the fact that sunlight activates nucleotide excision repair.
Through a procedure known as nucleotide excision repair, the genetic damages caused by UV radiation are frequently repaired shortly after they are created. The lesion is recognized and excised from a section of DNA by a nuclease enzyme.
Mammals primarily use nucleotide excision repair (NER) to eliminate large DNA lesions from DNA, such as those caused by UV light, environmental mutagens, and some cancer chemotherapy adducts. The very skin cancer-prone hereditary condition xeroderma pigmentosum is linked to NER deficiency.
A DNA repair mechanism known as nucleotide excision repair is crucial for repairing DNA damages brought on by UV light.
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