Question

Predict the effect of a substance that inhibits sodium channels from opening. How might this substance affect the way the nervous system functions?

Description:
The movement of sodium and potassium ions is an important part of how a neuron generates an action potential. Their movement is controlled by three transport proteins.

Answer 1

The effect of substance that inhibits sodium channels from opening would lead to reduction of cell excitability.

What are sodium channels?

The sodium channels are gated channels found in the cell membrane that allows the controlled passage of sodium ions to and from the cell of the body.

Sodium ions are one of the most important electrolyte of the body which helps in the maintenance of body fluid balance.

The opening and closing of the sodium channels helps in their regulation.

The substances that inhibit these sodium channels prevents the passage of sodium ion into the cell leading to the following effects:

• Slows the rate and amplitude of initial rapid depolarization,

• Reduction of  cell excitability, and

• Reduction of conduction velocity.

This substance that inhibits sodium channels affects the nervous system functions because they block nerve conduction and thereby block sensation in the area innervated by affected nerve fibers.

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