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Flu-like Symptoms may occur during the acute viral infection stage of human immunodeficiency virus infection.

The initial stage of HIV infection is known as acute HIV infection, and it typically appears 2–4 weeks after HIV infection. Some people experience flu-like symptoms at this time, including fever, headache, and rash. HIV multiplies quickly during the acute stage of infection and spreads all over the body.

The immune system's infection-fighting CD4 cells (CD4 T lymphocytes) are attacked and destroyed by the virus. The risk of HIV transmission significantly rises during the acute HIV infection stage due to the extremely high HIV blood levels. If ART is initiated at this point, a person might have major health benefits.

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