Question

Suppose an assassin uses ricin, a translation inhibitor, to poison her victim. Place the events in chronological order, starting from the poisoning and ending with the death of the victim.

Answer 1

The chronological order of events starting from poisoning should be as follows:

1. Ricin enters the victim's body
2. Ricin is absorbed into the blood and enters the cells
3. Ricin binds to ribosomes in the cytoplasm
4. Ricin inactivates 28s rRNA in the large subunits of the ribosomes
5. Ribosomes are unable to add new amino acids to polypeptides
6. Protein synthesis halts in many tissues
7. Multiple organ systems fail
8. The victim dies

Ricin is a plant toxin. It is poisonous to mammalian cells as it interferes with the catalytic activity of ribosomes in protein synthesis. It irreversibly binds to the ribosomal subunits and halts the polypeptide synthesis process, leading to cell death.

Note: Your question is incomplete, but probably it includes the following options:

a. Ricin is absorbed into the blood and enters the cells

b. Ricin inactivates 28s rRNA in the large subunits of the ribosomes

c. Ricin binds to ribosomes in the cytoplasm

d. Ricin enters the victim's body

e. Multiple organ systems fail

f. Protein synthesis halts in many tissues

g. The victim dies

h. Ribosomes are unable to add new amino acids to polypeptides

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