Most transmembrane proteins have hydrophilic regions facing the intra- and extracellular fluid, and hydrophobic regions embedded in the phospholipid bilayer.
Transmembrane proteins are membrane proteins that surrounds the entire entity of the cell connecting both the outside and the inside of the cell.
The hydrophilic regions are the regions that are water loving which faces the intra- and extracellular fluid.
The hydrophobic regions are the regions that repels water and they are found within the phospholipid bilayer.
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