Answer:
Yes, this is plenty of time for the humans in Mars to revolve differently. Due to Mars having different features (plants, air quality, etc) the people on Mars may develop differently to aid them in living on a different planet. They may develop a different variation of lungs to help them breathe better. Another possibility is a development that allows them to store water linger due to possible lack of water. In this span of time, humans on Mars may have begun developing these difference tools. As a result, in many years after the humans on Mars could almost be completely unrecognizable to the humans on Earth.