The specific DNA feature of the sickle cell mutation that allowed us to distinguish between HbA and HbS alleles is a single amino acid.
Sickle cell anemia is a disease in which the blood cells become sickle shaped. The disease is genetic.
The genes responsible for sickle cell anemia is HbS allele. HbA allele is responsible for normal cells.
Thus, the specific DNA feature is a single amino acid.
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