The tumors support their general proliferation by producing a growth element that they also respond to, this mechanism is called autocrine signalling.
Autocrine signaling means the display and secretion of an extracellular intermediate by a cell followed by the binding of that mediator to receptors on the same cell to start signal transduction.
A form of autocrine signaling is the secretion of IL-1 by macrophages.
Thus, this mechanism is called autocrine signalling.
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