What precautions need to be taken for working with the nucleophilic medium? What does it consist of?

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30-11-2021
Chemistry

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What precautions need to be taken for working with the nucleophilic medium? What does it consist of?

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adioabiola adioabiola · Answer 1 · 2021-12-01T11:59:53+01:00

A precaution that needs to be taken for working with the nucleophilic medium is ensuring the stability of the carbonation intermediate formed and Steric hindrance.

Discussion:

The likelihood of a nucleophilic substitution reaction proceeding by a dissociative mechanism depends to a large degree on the stability of the carbocation intermediate that forms.

Steric hindrance: Reactions where nucleophiles attack carbon-based electrophiles are significantly more sensitive to steric effects, because empty orbitals on carbon are not as accessible.