Question

Suppose that there is a mutation in a suppose that there is a mutation in a single-celled organism where the Krebs cycle (TCA/Citric Acid Cycle) doesn't happen. What would be the consequences for that organism? How would their metabolism be similar to ours? How would it be different?

Answer 1

In this case, the organism would not be able to produce ATP in aerobic conditions. The Krebs cycle is fundamental in humans.

Cellular respiration consists of a series of metabolic reactions by which aerobic cells can produce ATP (the energy coin of the cell) by using the energy stored in foods and oxygen.

Cellular respiration has three types of sequential reactions: glycolysis, the Krebs cycle and oxidative phosphorylation.

During the Krebs cycle, the energy from foods (e.g., carbohydrates) is released through the oxidation of acetyl-CoA.

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