What made him give up for good was when the entire DeLacey family left to live elsewhere.
We can arrive at this answer because:
However, when DeLacey's family returned to the cabin, everyone was horrified by the creature's appearance and threw him out. While that wasn't enough to make the creature give up on the company, the moment he saw that DeLacey had agreed to move and leave the cabin for good, he realized he would never be accepted by anyone and decided to give up everything forever.
This question is about "Frankenstein" and you can find more information at the link:
https://brainly.com/question/2503906