When acetylcholine stimulates its receptors in the neuromuscular junction then the permeability of the sarcolemma to Na+ increases. Acetylcholine is a key neurotransmitter of the parasympathetic nervous system.
The sarcolemma is the cell membrane of muscle cells.
Acetylcholine is a key neurotransmitter of the parasympathetic nervous system that is involved in diverse functions including the contraction of the smooth muscle cells.
In the neuromuscular junction (motor end-plate), motor neurons release acetylcholine, and therefore more sodium (Na+) ions move in than potassium (K+) out within the muscle cell.
This situation produces an electrochemical gradient across the sarcolemma, generating the local depolarization of the motor end-plate.
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