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If a female cat does not get out to mate during her first heat, she will continue to go through a heat cycle every few weeks until she becomes pregnant or is spayed. ... Over time, this may be stressful and unhealthy for the cat. She may lose weight, begin overgrooming, and even develop behavior issues. A male cat cannot mate with a female that is not in heat. Unless the female is receptive to mating, she will not let him mount her. ... There is no exact age when a cat will begin her first heat. If there's even a marginal chance that she could go into heat before the male is fixed.

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