The stratum spinosum is a layer of the epidermis localized between the stratum granulosum and stratum basale. It consists of differentiated cells called keratinocytes.
- After a stem cell divides in the stratum basale, the resulting daughter cell enters the stratum SPINOSUM and it begins to lose its ability to divide.
- Keratinocytes are cells localized in the outermost layer of the epidermis (i.e., the skin).
- Keratinocytes are completely differentiated epithelial cells (i.e., they cannot divide).
- In consequence, keratinocyte replacement entirely depends on epidermal stem cells.
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