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Many maintain that the primary cause of the war was the Southern states' desire to preserve the institution of slavery. Others minimize slavery and point to other factors, such as taxation or the principle of States' Rights.

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Answer:

If you are referring to the Civil War...

Explanation:

The secession began with the disagreement between the geographic north and south of the United States.

The main two disagreements between both sides were the issue of slavery and the issue of state's rights.

South -> Wanted more state rights

North -> Wanted to abolish slavery

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