Question

If Substance A has an LD50 of 20 mg/kg of body mass, and Substance B has an LD50 of 10 mg/kg of body mass, which substance is considered more deadly? Substance A is deadlier than Substance B. Substance B is deadlier than Substance A. Both substances are equally deadly enough to half a population. Neither of them are deadly because they do not reach at least 50 mg/kg.

Answer 1

• LD50 means a lethal dose of a particular substance or drug is given to a group of animals in a test group. This dose has the ability and capacity to kills 50% of the population of the test group of animals.

• If Substance A has an LD50 of 20 mg/kg of body mass, this means that for 1 kg of body mass, 20 mg of substance A can kill 50% of the population that substance A was given to the test group.  

• If Substance B has an LD50 of 10 mg/kg of body mass, this means that for 1 kg of body mass, 10 mg of substance A can kill 50% of the population that substance B was given to the test group.

Therefore, Substance B is deadlier than Substance A because the quantity of substance B (10mg) is less than the quantity of Substance A (20mg) and it has the same lethal effect on the population.

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