The reason why damage to the kidney by a toxicant is often site-selective is that each of these parts comprises distinct variations in blood flow and transportation, physiochemical features of the epithelium, varying cellular reactivity, and detoxification reactions. etc.
The kidney is a two-sided bean-shaped organ located posteriorly to the abdomen. Its main function is for filtration of blood and removal of waste materials thereby maintaining the balance of body fluid.
The kidney consists of the following parts.
- renal corpuscle which is further subdivided into the glomerulus and the bowman's capsule.
- renal tubules:- comprises of proximal convoluted tubules, the loop of Henle, distal convoluted tubules.
- renal cortex
- renal medulla
- renal pelvis
- ureter
Toxicants are harmful and poisonous substances that are capable of causing detrimental effects to normal health status.
Therefore, we can conclude that the reason why damage to the kidney by a toxicant is often site-selective is that each of these parts comprises distinct variations in blood flow and transportation, physiochemical features of the epithelium, varying cellular reactivity, and detoxification reactions.
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