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The event that serves as one major factor leading to the need for building codes and government regulation of businesses is known as "the 1886 Chicago Fire."

This is because, following the event of the 1886 Chicago Fire, there were needs to prevent similar occurrences hence, the promulgation of building codes was made at the time.

Similarly, during this period, the business of insurance was coming up, and the government felt the need to ensure there is fewer payouts of insurance. Hence, by the year 1915 the Building Officials and Codes Administrators, International  (BOCA) was formulated, with subsequent codes.

Therefore, the event that serves as one major factor leading to the need for building codes and government regulation of businesses is known as "the 1886 Chicago Fire."

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