Which one of the following statements concerning vitamin B12 is correct?
A\ it is present in plant products.
B\ its deficiency is most often caused by a lack of the vitamin in the diet.
C\ it requires a specific glycoprotein for its absorption.
D\ it is involved in the transfer of amino groups.
E\ the cofactor from is vitamin B12 itself.

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Answer:

C it requires a specific glycoprotein for its absorption.

Out of the following statements concerning vitamin B12 the only statement which is correct- it requires a specific glycoprotein for its absorption.

Let's study some facts about vitamin B12:

  • Vitamin B12 is an essential vitamin found in foods such as meat, fish, and dairy.
  • It requires a specific glycoprotein for its absorption. The body absorbs vitamin B12 from food in a two-step process.

⇒First, hydrochloric acid in the stomach separates vitamin B12 from the protein that it's attached to.

⇒Second, the freed vitamin B12 then combines with a protein made by the stomach, called intrinsic factor, and the body absorbs them together.

  • Deficiency of Vitamin B12 leads to weakness and fatigue.
  • Transport of B12 in extracellular fluids is dependent on three homologous carrier proteins:

intrinsic factor, transcobalamin (also known as transcobalamin II), and haptocorrin (also known as the R-protein or transcobalamin I).

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