There are now several effective antimalarial drugs that can treat people who have malaria or prevent them from getting the disease altogether. Predict what will happen to the frequency of the sickle cell allele over the next 100 years as these drugs become more widely used by people living in areas where malaria is endemic: ___ Predict what will happen to the frequency of the sickle cell allele over the next 100 years in areas like Boston MA, where there is no incidence of malaria: stay the same ; stay the same decrease ; increase increase ; increase increase ; decrease decrease ; decrease

By using antimalarial drugs in order to prevent malaria, the frequency of the sickle cell allele decreases in both areas where malaria is endemic and the areas where no incidence of malaria occurs because there is no necessity of sickle cell allele in the population to prevent malarial disease. Sickle cells have high significance in prevention of malarial diseases so when there is no malaria happens in the population so there is no need for it and the allele slowly removed from the population and decrease occurs in its frequency.