Answer: it is so harsh that it may cause the protagonist's death.
Explanation:
The sentence that best describes the importance of the setting of Julie of the Wolves is option A "it is so harsh that it may cause the protagonist's death".
Julie was faced with a predicament. It was very cold and freezing and a mistake from her could lead to her death. Also, I he setting shows that the only individual was Julie as there was no one else except the animals.