Answer:
Stellate cells are resident lipid-storing cells of the pancreas and liver that transdifferentiate to a myofibroblastic state in the context of tissue injury. Beyond having roles in tissue homeostasis, stellate cells are increasingly implicated in pathological fibrogenic and inflammatory programs that contribute to tissue fibrosis and that constitute a growth-permissive tumor microenvironment. Although the capacity of stellate cells for extracellular matrix production and remodeling has long been appreciated, recent research efforts have demonstrated diverse roles for stellate cells in regulation of epithelial cell fate, immune modulation, and tissue health. Our present understanding of stellate cell biology in health and disease is discussed here, as are emerging means to target these multifaceted cells for therapeutic benefit.
The stellate cells plays a crucial role in liver fibrosis.
Hepatic stellate cells is also known as perisinusoidal cells. The stellate cell is a type of cell that is involved in liver fibrosis, which is the formation of scar tissue in response to liver damage. These stellate cells promote the development of liver injury by secreting pro-inflammatory cytokines.
These cells have no function of communication. The stellate cell is also responsible for the secretion of collagen scar tissue, which results in cirrhosis in which the scar tissue takes the place of healthy tissue and the liver is damaged permanently. Stellate cells are responsible for healing of certain type of damages in the liver.
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