Question

What are examples of tumor suppressor genes, in which mutations correlate with cancer?

A. BBBC 1 and BBBC 2
B. BARC 1 and BARC 2
C. No cells are correlated with cancer
D. BRCA 1 and BRCA 2

Answer 1

Two genes, BRCA1, located on chromosome 17q21 (5,6), and BRCA2, located on 13q12-13 (7–9), have been shown to predispose to familial breast cancer.