The function of acetylcholinesterase in the synaptic left is to bind Ach receptors on the post-synaptic membrane and relays signal from the nerve. Acetylcholinesterase is an enzyme that catalyzes the breakdown of acetylcholine. Some other cholines functions as neurotransmitters. ACHE gene is found in the chemical synapses and neuromuscular junctions of cholinergic. Acetylcholinesterase belongs to carboxylesterase group of enzymes. During the time of neurotransmission Ach which is released from presynaptic neuron to synaptic cleft. Acetylcholinesterase is also found in red blood cells membranes whereby different forms constitute the Y blood group antigens.