Respuesta :

First used in 1821 the Santa Fe Trail was an important trade route that connected Missouri with Mexico

Answer:

What trade routes connected missouri to mexico in 1821?

Explanation:

The Santa Fe Trail was opened in 1821, was a famous route of transport of the XIX century that ran through the center of North America, connecting the cities of Independence (now Missouri) and Santa Fe (today New Mexico).

The answer is: The Santa Fe Trail was opened in 1821.

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