Seudónimo Seudónimo 28-01-2021 History contestada Want brainliest get this right How did the Lewis and Clark expedition influence the boundaries of the United States in early 19 th century? Their success and discoveries opened the west for settlement of territories. Their defense of New Orleans led to the American victory in the War of 1812. Their disappearance on the frontier discouraged American settlers and farmers from moving west. Their expedition into foreign lands led to conflicts where the U.S. lost territory to France.