Question

What would happen to an enzyme if the pH or even temperature of the environment totally cause the enzyme to stop working? Please answer in terms of the active site and what is happening to the enzyme shape.

Answer 1

The enzyme will become denatured, causing it's shape to deform. Now the substrate won't be able to fit in the active site due to the change in shape.

Answer 2

Answer:

The enzyme predicted its three-dimensional structure, making it impossible for its active site to match the substrate needed to carry out its biological reaction.

Explanation:

If pH or temperature disables enzyme functionality, it means that the enzyme has been denatured and has lost its three-dimensional structure. In this way the enzyme became deformed and its active site completely changed its shape. As you may know the active site of the enzymes is the perfect fit for a substrate type, if the enzyme becomes deformed the active site will also be deformed and will not be able to fit with the substrate, in this case the enzymatic reaction is impossible to happen.