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Answer:
Leptin is a protein hormone composed of 167 amino acids of the cytosine family, it is synthesized mainly by white adipose tissue. The leptin receptor is related to that of receptors for cytosines (since it uses Janus or JAK type kinases and STAT-3 proteins as intracellular mediators of transcription pathway), it is predominantly found in the hypothalamus (particularly in the arcuate nucleus and to a lesser extent in the nuclei dorsomedial and ventromedial), hippocampus and cerebellum. There is evidence that leptin acts at the level of the arcuate nucleus, preventing the formation of NPY.
Explanation:
Leptin is produced exclusively in adipose tissue cells in a wide variety of species, including humans, and its concentration is higher in overweight than in lean individuals. The biological actions of leptin can be classified into two groups, those that are exerted in the tissues of the central nervous system, mainly the hypothalamus, and those that are carried out on the peripheral tissues. The former regulate body weight downward, decrease food intake, increase basal energy expenditure and modify some neuroendocrine functions such as reproduction, while the latter have effects on proliferation, differentiation and metabolism of peripheral tissues. The leptin that reaches the hypothalamus, in addition, inhibits protein synthesis and the secretion of neurons producing NPY / AgRP of the arcuate nucleus and stimulates the synthesis and secretion of those containing POMC. NPY (neuropeptide Y) is produced in the hypothalamic arcuate nucleus. This neurotransmitter arrives through the projections of the neurons of said nucleus to the paraventricular nucleus, which is the area where it is released. There are several studies that have shown that an increase in NPY leads to an increase in the sensation of hunger and thus to hyperphagia and obesity. Leptin acts at the level of the arcuate nucleus, preventing the formation of NPY. The leptin receptor lacks enzymatic activity in its intracellular domain. Instead, it is linked to members of the janus kinase family, which belong to a class of tyrosine kinases. The binding of the ligand activates the Jak kinase and leads to the phosphorylation of certain cytoplasmic proteins. Within these proteins there is a class of cytoplasmic transcription factors called signal transducers and activators of transcription (STAT).
A protein hormone synthesized majorly by white adipose tissue is leptin. It is secreted from the fat cells or adipose tissue of the body and concerns fat and obesity.
The obese individual has a high amount of leptin compared to a lean person.
The leptin works on tissues of the CNS mainly the hypothalamus and PNS. Leptin binds to members of the Janus kinase family of the tyrosine kinases class.
The ligand-binding triggers the Jak kinase and results in the phosphorylation of specific cytoplasmic proteins that includes the class of cytoplasmic transcription factors named signal transducers and activators of transcription (STAT).
CNS controls body weight, reduce food intake, improve basal energy expenditure and modify some neuroendocrine processes like reproduction.
PNS affects the expansion, metabolism and differentiation of peripheral tissues.
The leptin that moves towards the hypothalamus impedes protein synthesis and the secretion of neurons producing NPY / AgRP.
NPY (neuropeptide Y) is formed in the hypothalamus and arrives through the outgrowths of the neurons of the arcuate nucleus. It moves towards the para-ventricular nucleus from where it is released.
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