Answer: Transcription factor
Explanation:
In the two-hybrid screening technique, the type of protein that is separated into two different domains to determine if two other proteins attached to these domains will interact is called the transcription factor.
Transcription factors are the proteins that helps in the conversion of DNA into RNA or their transcription. Transcription factors simply consist of a large number of proteins, that initiate are used in regulating gene transcription. It should be noted that a characteristics of the transcription factors is the possession of DNA-binding domains.