Answer:
According to the pedigree, It is clear that the F1 generation is not affected but their offspring are affected in F2, which explains that the deafness presented with the pedigree is recessive. It should be an Autosomal recessive inheritance as it is found in both male and female offsprings.
As it is found that the parents are affected in 5th gen and 6th generation but their offspring are not affected which means there must be more than one genes controlled this disorder
B. In 5th generations mentioned above offspring is unaffected but parents are affected, to find the genotype of the individual let assume there are two genes responsible for it A and B, and mutation in any one of them can result in deafness.
So in IV generation Individuals 5 and 6 have genotypeAAbb and aaBB; both are deaf.
gametes:- Ab & aB.
So, the genotype of all offsprings will be AaBb means all are normal.
Deafness is an autosomal recessive disorder as the first generation is unaffected and the genotype of the fifth generation is AaBb.
Pedigree is a chart representation of the phenotype of specific genes of the organism and its inheritance from the ancestral family. The pedigree can be used for the analysis of the heritable disease and illness in the family root.
The deafness illness in the pedigree is recessive as the first generation of the pedigree remains unaffected but the later generation is affected and is diseased.
From the chart, deafness can be said to be an autosomal recessive disorder as some generations are unaffected and in some the disease is present. More than one gene is controlling the disease as the fifth and sixth generations are affected but not their offspring.
The parent of the fifth generation are affected but their progenies are normal to know the genotype let's assume the genes A and B to be responsible for the disease and the mutation in any one of the alleles will result in deafness.
Hence, the genotype of the parents 5 and 6 in the fourth generation will be AAbb and aaBB as both of them diseased or deaf, the offsprings produced from their cross will be AaBb that is all the offspring of the fifth generation will be normal and unaffected.
Therefore, the genotype of the fifth generation in the pedigree is AaBb.
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