Answer:
D.The Spanish missions were established to govern Spain’s colonies but caused the collapse of Mississippi Indians by spreading European diseases to a population with no immunity to them.
Explanation:
Spanish missions were catholic churches established by the Spanish crown with the aim of colonizing the Native Indians in North America. They spread the Catholic doctrine to them, thus overriding their traditional worship of gods and idols.
The Native Indians attended these churches and gradually the Spanish people introduced their culture to them. A limiting factor to this development was the introduction of diseases by the Europeans to the Native Indians who had no immunity to the diseases and this led to the death of many of the natives.