Why were American Indians so heavily impacted by European diseases?
Most American Indian groups were surrounded by European settlements and were unable to escape infection.
American Indians lacked immunity to the diseases because they had never been exposed to them before.
Most American Indians failed to treat the diseases early on because they did not believe in medicine.
American Indians were unable to communicate with Europeans and did not understand what was happening.

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Answer:

American Indians lacked immunity to the diseases because they had never been exposed to them before.

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