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Answer:
C
Explanation:
The active site of the enzyme is the critical region where the substrate binds and the chemical reaction takes place.
a. In the reaction above, the active site is represented by letter 'E' - this is true
b. The active site is highly variable in shape to accommodate many different enzymes - this is false. The active site is usually highly specific for a certain substrate
c. The active site is the location where the enzyme and substrate molecule interact - this is true
d. The shape of the active site is susceptible to changes in temperature and/or pH - this is true, the catalytic activity of an enzyme often only works under very specific conditions