Question

Which of the following polypeptides is most likely to form an α-helix explain your answer.(a) CRAGNRKIVLETY (b) SEDNFGAPKSILW (c) QKASVEMAVRNSG

Answer 1

Answer:

(c) QKASVEMAVRNSG

Explanation:

The alpha helix is a protein arrangement tightly packed, thereby the peptide will form a rod. The option (c) is expected to form an alpha helix because it contains three amino acids charged which are aligned on the face of the helix, 1-two residues positively charged: Lysine (K) and Arginine (R), and 2-one residue negatively charged: Glutamic Acid (E).

Answer 2

The following polypeptides are most likely to form an α-helix explain your answer - (c) QKASVEMAVRNSG

Destabilization of α-helices

The formation of alpha-helix required correct steric configuration. Amino acids with R-groups are too large like tryptophan, and tyrosine or too small glycine destabilize α-helices.

Proline also destabilizes α-helices has irregular geometry and causes steric hindrance because its R-group bonds back to the nitrogen of the amide group.

Option(A) CRAGNRKIVLETY

There is Glycine in this sequence, so it can not form an alpha helix.

Option (B): SEDNFGAPKSILW

The presence of glycine and proline causes not to form an alpha helix.

Option (C): QKSVEMAVRNSG

Glycine is present but still, it is most likely to form an alpha helix as glycine is the end of the sequence.

Find more information about a-helices:

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