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The four levels of protein structure are distinguished from one another by the degree of complexity in the polypeptide chain. A single protein molecule may contain one or more of the protein structure types: primary, secondary, tertiary, and quaternary structure. 1. Primary Structure: describes the unique order in which amino acids are linked together to form a protein.

2. Secondary Structure: refers to the coiling or folding of a polypeptide chain that gives the protein its 3-D shape. There are two types of secondary structures observed in proteins. One type is the alpha (α) helix structure. This structure resembles a coiled spring and is secured by hydrogen bonding in the polypeptide chain. The second type of secondary structure in proteins is the beta (β) pleated sheet. This structure appears to be folded or pleated and is held together by hydrogen bonding between polypeptide units of the folded chain that lie adjacent to one another

3. Tertiary Structure: refers to the comprehensive 3-D structure of the polypeptide chain of a protein.

4. Quaternary Structure: is the structure of a protein macromolecule formed by interactions between multiple polypeptide chains. Each polypeptide chain is referred to as a subunit. Proteins with quaternary structure may consist of more than one of the same type of protein subunit.

The four levels of protein structure are the

  • primary, secondary, tertiary, and quaternary structures.

Primary structure: The Primary structure is the basic sequence of amino acids that form a polypeptide chain. There are basically 20 amino acids in a protein.

Secondary structure: This is the regular pattern of folding in the basic structure of a protein. The foldings occur as the alpha and beta sheets.

Tertiary structure: This is the 3 dimensional folding of the polypeptide chain as found in most enzymes.

Quaternary structure: This protein structure is formed from two or more polypeptide chains. The hemoglobin molecule is an example.

In conclusion, the four levels of protein structure are the primary, secondary, tertiary, and quaternary structures.

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