Question

Put the following events describing the process of mRNA degradation by miRNA in sequential order.

1 the mRNA is degraded or translation of the mRNA is halted
2 an enzyme, Dicer, cleaves the precursor miRNA in small fragments
3 miRNA binds to the mRNA
4 one strand of the miRNA binds a protein complex, the other strand is degraded
5 a precursor miRNA forms a hairpin loop
Select one:

a. 3, 2, 4, 5, 1
b. 2, 5, 4, 1, 3
c. 5, 4, 2, 1, 3
d. 2, 5, 4, 3, 1
e. 5, 2, 4, 3, 1

Answer 1

E. 5, 2, 4, 3, 1 because the mRNA isn’t degraded / translation doesn’t stop till the last step so 1 has to be last and 5 has to be first because the replication fork has to be formed before anything else can occur