Question

Inosine monophosphate is a branch point for the synthesis of a variety of purine nucleotides. Match the appropriate reaction for the synthesis of either AMP or GMP:
1) AMP A) condensation with Asp
2) GMP B) oxidative hydration
C) transamination with Gln
D) release of fumarate

1. --> 1:A, C; 2: B, D
2. --> 1:C, D; 2: A, B
3. --> 1:A, B; 2: C, D
4. --> 1:A, D; 2: B, C

Answer 1

Answer:

1:A, D; 2: B, C

Explanation:

1.Purine Bases Can Be Synthesized by two pathways: i) de Novo and ii) Salvage Pathways.

2.Purine nucleotides synthesis starts with Phosphoribosyl pyrophosphate (PRPP), and it leads to the synthesis of nucleotide, inosine 5'-monophosphate (IMP).  Inosine monophosphate is a branch point for the synthesis of many purine nucleotides amd leads to the synthesis of a variety of purine nucleotides.

3.The first reaction of purine synthesis is catalyzed by  the enzyme glutamine phosphoribosylpyrophosphate amidotransferase.