Question

All of the following are cofactors used in the reaction catalyzed by pyruvate dehydrogenase EXCEPT ________.

A. NAD+
B. Thiamine pyrophosphate
C. Biotin
D. FAD

Answer 1

Answer: Option B.

Thiamine pyrophosphate.

Explanation:

Pyruvate dehydrogenase is an enzyme that catalyses the oxidative decarboxylation of pyruvate to acetyl coA , NADH and CO2. Pyruvate dehydrogenase uses NAD, biotin, FAD and lipoic acid.

Thiamine pyrophosphate is not a cofactor for pyruvate dehydrogenase . It is a cofactor in living systems. Thiamine pyrophosphate is a coenzyme that function in carbohydrates, Amino acids and lipids metabolism.