Which of the following statements about the organization of the purine synthetic enzymes are true? The process involves multifunctional enzymes. The process involves reversible enzyme formations. High local concentrations are maintained through the sequence. The entire 10-step process requires only 6 enzymes. View Available Hint(s) Which of the following statements about the organization of the purine synthetic enzymes are true? The process involves multifunctional enzymes. The process involves reversible enzyme formations. High local concentrations are maintained through the sequence. The entire 10-step process requires only 6 enzymes. Only statements 1 and 2 are true. Only statements 1, 2, and 3 are true. Only statements 2, 3, and 4 are true. All of the listed statements are true.

Purines are biologically synthesized as nucleotides and in particular as ribotides, that is, bases attached to ribose 5-phosphate. Adenine and guanine are both derived from the nucleotide inosine monophosphate (IMP), which is the first compound in the pathway to have a completely formed purine ring system.

Purine nucleotides can be synthesized in two distinct pathways. First, purines are synthesized de novo, starting with simple starting materials such as amino acids and bicarbonate. the purine bases are assembled already attached to the ribose ring. Alternatively, purine bases, released by the hydrolytic degradation of nucleic acids and nucleotides, can be salvaged and recycled. Purine salvage pathways are mostly noted for the energy that they save and the remarkable effects of their absence.

All statements are correct because the organization of purine synthetic enzymes involves multifunctional enzymes, reversible enzyme formations, through out the sequence there is maintenance of high local concentration and the ten steps requires only six enzymes.