Question

Explain how the random alignment of homologous chromosomes during metaphase I
contributes to variation in gametes produced by meiosis.
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Answer 1

The randomness in the alignment of recombined chromosomes at the metaphase plate, coupled with the crossing over events between nonsister chromatids, are responsible for much of the genetic variation in the offspring. To clarify this further, remember that the homologous chromosomes of a sexually reproducing organism are originally inherited as two separate sets, one from each parent. Using humans as an example, one set of 23 chromosomes is present in the egg donated by the mother. The father provides the other set of 23 chromosomes in the sperm that fertilizes the egg. Every cell of the multicellular offspring has copies of the original two sets of homologous chromosomes. In prophase I of meiosis, the homologous chromosomes form the tetrads. In metaphase I, these pairs line up at the midway point between the two poles of the cell to form the metaphase plate. Because there is an equal chance that a microtubule fiber will encounter a maternally or paternally inherited chromosome, the arrangement of the tetrads at the metaphase plate is random. Thus, any maternally inherited chromosome may face either pole. Likewise, any paternally inherited chromosome may also face either pole. The orientation of each tetrad is independent of the orientation of the other 22 tetrads.

Explanation:

Answer 2

The assortment of homologous chromosomes during meiosis is random and generates genetic variation, the raw material for evolution.

During metaphase I of meiosis, homologous chromosomes are lined up at the equator plate of the cell in order to be separated (assorted) in anaphase I.

The separation of homologous chromosomes during meiosis I is random, thereby daughter cells receive different gene combinations from an original parent cell.

Subsequently, haploid cells obtained from two successive meiotic divisions fuse during fecundation to form a diploid (2n) zygote.

Moreover, during prophase I non-sister chromatids interchange genetic material by a process known as recombination, thereby this genetic process also increases genetic variation in daughter cells.

In conclusion, the assortment of homologous chromosomes during meiosis is random and generates genetic variation.

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