Answer:
Plasma concentration of IGF-1 is the right answer.
Explanation:
When pituitary gland produced excessive amount of Growth hormones is called Acromegaly.
The main cause of acromegaly is over producing Growth Hormones(GH)by the pituitary.when GH secreted into blood it influenced liver to produced insulin -like-growth factor-I(IGF-1).Then IGF-1 stimulates the growth of bones and tissue.
When pituitary produced large amount of GH it leads to overproduction of IGF-1.excessive of IGF-1 Cause abnormal growth of soft tissue and skeleton.